向精神薬服用患者の突然死症例におけるカリウムイオンチャネルに関する分子生物学的解析：QT延長症候群関連遺伝子の多型が危険因子となり得るか？

Psychotropic drugs can pose the risk of acquired long QT syndrome (LQTS). Unexpected autopsy-negative sudden death in patients taking psychotropic drugs may be associated with prolonged QT intervals and life-threatening arrhythmias. We analyzed genes that encode for cardiac ion channels and potentially associated with LQTS, examining specifically the potassium channel genes KCNQ1 and KCNH2 in 10 cases of sudden death involving patients administered psychotropic medication in which autopsy findings identified no clear cause of death. We amplified and sequenced all exons of KCNQ1 and KCNH2, identifying G643S, missense polymorphism in KCNQ1, in 6 of the 10 cases. A study analysis indicated that only 11% of 381 healthy Japanese individuals carry this polymorphism. Reports of previous functional analyses indicate that the G643S polymorphism in the KCNQ1 potassium channel protein causes mild IKs channel dysfunction. Our present study suggests that administering psychotropic drug therapy to individuals carrying the G643S polymorphism may heighten the risk of prolonged QT intervals and life-threatening arrhythmias. Thus, screening for the G643S polymorphism before prescribing psychotropic drugs may help reduce the risk of unexpected sudden death2013博士（歯学）松本歯科大

An Electrically Conductive Single-Component Donor–Acceptor–Donor Aggregate with Hydrogen-Bonding Lattice

An electrically conductive D–A–D aggregate composed of a single component was first constructed by use of a protonated bimetal dithiolate (complex <b>1H</b>_<b>2</b>). The crystal structure of complex <b>1H</b>_<b>2</b> has one-dimensional (1-D) π-stacking columns where the D and A moieties are placed in a segregated-stacking manner. In addition, these segregated-stacking 1-D columns are stabilized by hydrogen bonds. The result of a theoretical band calculation suggests that a conduction pathway forms along these 1-D columns. The transport property of complex <b>1H</b>_<b>2</b> is semiconducting (<i>E</i>_a = 0.29 eV, ρ_rt = 9.1 × 10⁴ Ω cm) at ambient pressure; however, the resistivity becomes much lower upon applying high pressure up to 8.8 GPa (<i>E</i>_a = 0.13 eV, ρ_rt = 6.2 × 10 Ω cm at 8.8 GPa). The pressure dependence of structural and optical changes indicates that the enhancement of conductivity is attributed to not only an increase of π–π overlapping but also a unique pressure-induced intramolecular charge transfer from D to A moieties in this D–A–D aggregate

An Electrically Conductive Single-Component Donor–Acceptor–Donor Aggregate with Hydrogen-Bonding Lattice

An electrically conductive D–A–D aggregate composed of a single component was first constructed by use of a protonated bimetal dithiolate (complex <b>1H</b>_<b>2</b>). The crystal structure of complex <b>1H</b>_<b>2</b> has one-dimensional (1-D) π-stacking columns where the D and A moieties are placed in a segregated-stacking manner. In addition, these segregated-stacking 1-D columns are stabilized by hydrogen bonds. The result of a theoretical band calculation suggests that a conduction pathway forms along these 1-D columns. The transport property of complex <b>1H</b>_<b>2</b> is semiconducting (<i>E</i>_a = 0.29 eV, ρ_rt = 9.1 × 10⁴ Ω cm) at ambient pressure; however, the resistivity becomes much lower upon applying high pressure up to 8.8 GPa (<i>E</i>_a = 0.13 eV, ρ_rt = 6.2 × 10 Ω cm at 8.8 GPa). The pressure dependence of structural and optical changes indicates that the enhancement of conductivity is attributed to not only an increase of π–π overlapping but also a unique pressure-induced intramolecular charge transfer from D to A moieties in this D–A–D aggregate